EXPOSOME SYMPOSIUM

Emerging Challenges in Implementing the Exposome

October 20-21, 2022

Nouvelle Faculté de Médecine, Université de Montpellier (UM), Montpellier, France | Hybrid Event
Topic

IDESP Exposome Symposium

Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to chronic diseases. The final aim is to help protect people at a societal level. However, the process of putting the emerging exposome approach to work in scientific research is hardly straightforward. There are many challenges to capturing the complexity of exposures in an individual across the lifetime and their potential health effects. The purpose of the forthcoming workshop is to collect scientists involved in building the exposome in the case of chronic diseases from fields ranging from clinical medicine, epidemiology, toxicology and omics to statistics, bioinformatics to review the state of the science in the emerging field of exposomics. The workshop will present the ongoing exposomics projects and initiative, including the GLOBAL EXPOSOME PLATEFORM.

Definition of Exposome
The exposome can be defined as the measure of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.
Organization

Institute Desbrest of Epidemiology and Public Health, University of Montpellier, INSERM, Montpellier, France

IDESP-Logo - Copie

Pr Isabella Annesi-Maesano

IDESP, University of Montpellier (UM) & INSERM, Montpellier, France

Pr Grégory Ninot

IDESP, University of Montpellier (UM) & INSERM, Montpellier, France

Laura Cerramon

IDESP, University of Montpellier (UM) & INSERM, Montpellier, France

Sylvie Barthelemy

IDESP, University of Montpellier (UM) & INSERM, Montpellier, France
Why Montpellier?
Montpellier is renowned for its historical excellence in the fields of health and environmental sciences, and for its modern capacity to bring the two together, under the umbrella of the Montpellier University of Excellence program, the Muse I-SITE program. The exposome is at the heart of this juncture. Around the Metropole of Montpellier itself, the French Region of Occitaniehosts a variety of proactive university laboratories and health-related companies. Healthcare institutions are also highly involved in clinical research. This economic and research cluster stimulates innovation and research.

PROGRAM

Venue: Montpellier, Nouvelle Faculté de Médecine

14:00 - 14:30

Opening Ceremony

Isabella Annesi-Maesano and Pascal Demoly IDESP, University of Montpellier (UM) & INSERM, Montpellier, France
Representive, Occitanie Region
Representive, Metropole Montpellier
Remy Slama Director ITMO Santé Publique INSERM
Jacques Mercier Vice-President Recherche UM
Isabelle Laffont Dean Faculté de Médecine UM
Jacques Cavaillé Délégué Régional Occitanie Méditerranée INSERM

14:30 - 16:00

Principles of Exposomics

Chair: Marco Martuzzi ISS, Rome, Italy
Discussant: Yuxia Cui NIEHS, Durham, NC, USA

Lecture 1: Gary Miller Columbia University, New York, USA

Lecture 2: Chirag Patel Harvard University, Boston, USA

16:00 - 16:30 Hall

BREAK

16:30 - 18:00

Critical windows of exposure: assessments and effects

Chair: Isabella Annesi-Maesano IDESP, INSERM & UM, Montpellier, France
Discussant: Paolo Vineis Imperial College, London, UK

Lecture 1: Martine Vrijheid ISGLOBAL, Barcelona, Spain

Lecture 2: Michael Jerret UCLA, Los Angeles, USA

08:30 - 10:00

Round Table: Exposome panorama in the world

Chair: Heimo Muller University of Graz, Austria
Discussant: Yuxia Cui NIEHS, Durham, NC, USA

Sophie Lanone Remedia
Gianluca Severi E3N and E4N
Gary Miller ERACLES
Martine Vrijhei HELIX and ATHLETE
Mircea Sofonea Expos’UM
Sylvain Sebert LONGITOOLS
Heikki Hyöty HEDIMED
Anjoeka Pronk and Eelco Juijpers EPHOR
Peter Hoet EXIMIOUS
Irene van Kamp EQUAL-LIFE
Jelle Vlaanderen and Roel Vermeulen EXPANSE
Zisis Kozlakidis HEAP
Isabella Annesi-Maesano and Denis Sarigiannis HEALS
Paolo Vineis EXPOSOMICS

10:00 - 10:30 Hall

BREAK

10:30 - 12:00

Causal estimates from high-dimensional heterogeneous data

Chair: Marc Chadeau Imperial College, London, UK
Discussant: David Causeur Agrocampus Ouest, Rennes, France

Lecture 1: Jelle Vlaanderen Utrecht University, Utrecht, The Netherlands

Lecture 2: Julie Josse IDESP, Montpellier, France

Lecture 3: Zeno Loi and Nicolas Molinari IDESP, Montpellier, France

12:00 - 13:00

The European Human Exposome Network

Chair: Yuxia Cui NIEHS,Durham, NC, USA
Introductory talk: Rita Araujo EC, Brussels, Belgium

Lecture 1: Data Harmonisation, FAIRificaton and Provenance Management (in Exposome Research)
Heimo Muller
University of Graz, Austria

Lecture 2: HEAP data life-cycle: From data to knowledge discovery (for Exposome Research)
Roxana Martinez
Karolinska Institute, Stockholm, Sweden

General discussion: All the Exposome projects

13:00 - 14:00

Lunch

14:00 - 15:30

Applying Exposomics to positively impact human health through recommendations and policy

Chair: Grégory Ninot IDESP, Montpellier, France
Discussant: Marco Martuzzi ISS, Rome, Italy

Lecture 1: Paolo Vineis Imperial College, London, UK

Lecture 2: The public health exposome: a population-based, exposure science approach to health disparities research,
Paul Juarez Research Center on Health Disparities, Equity, and the Exposome, Memphis, USA

15:30 - 16:00 Hall

Break

16:00 - 17:00

General discussion about unmet needs, projects and conclusion

Chair and discussant: Isabella Annesi-Maesano IDESP, INSERM et UM, Montpellier and Daniele di Pietro IMAG, CNRS, UM, Montpellier

Rémy Slama, ITMO SP, INSERM, Paris
Eric Delaporte INSERM, IRD, UM, Montpellier
Marc Chadeau Imperial College, London, UK
Robert Barouki INSERM, Paris, France

General discussion
Wrap-up

17:00 - 17:15

End of the symposium

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