Emerging Challenges in Implementing the Exposome
October 20-21, 2022
Nouvelle Faculté de Médecine, Université de Montpellier (UM), Montpellier, France | Hybrid Event
IDESP Exposome Symposium
Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to chronic diseases. The final aim is to help protect people at a societal level. However, the process of putting the emerging exposome approach to work in scientific research is hardly straightforward. There are many challenges to capturing the complexity of exposures in an individual across the lifetime and their potential health effects. The purpose of the forthcoming workshop is to collect scientists involved in building the exposome in the case of chronic diseases from fields ranging from clinical medicine, epidemiology, toxicology and omics to statistics, bioinformatics to review the state of the science in the emerging field of exposomics. The workshop will present the ongoing exposomics projects and initiative, including the GLOBAL EXPOSOME PLATEFORM.
The exposome can be defined as the measure of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.
Montpellier is renowned for its historical excellence in the fields of health and environmental sciences, and for its modern capacity to bring the two together, under the umbrella of the Montpellier University of Excellence program, the Muse I-SITE program. The exposome is at the heart of this juncture. Around the Metropole of Montpellier itself, the French Region of Occitaniehosts a variety of proactive university laboratories and health-related companies. Healthcare institutions are also highly involved in clinical research. This economic and research cluster stimulates innovation and research.
PROGRAM
Venue: Montpellier, Nouvelle Faculté de Médecine
Opening Ceremony
Isabella Annesi-Maesano and Pascal Demoly IDESP, University of Montpellier (UM) & INSERM, Montpellier, France
Representive, Occitanie Region
Representive, Metropole Montpellier
Remy Slama Director ITMO Santé Publique INSERM
Jacques Mercier Vice-President Recherche UM
Isabelle Laffont Dean Faculté de Médecine UM
Jacques Cavaillé Délégué Régional Occitanie Méditerranée INSERM
Principles of Exposomics
Chair: Marco Martuzzi ISS, Rome, Italy
Discussant: Yuxia Cui NIEHS, Durham, NC, USA
Lecture 1: Gary Miller Columbia University, New York, USA
Lecture 2: Chirag Patel Harvard University, Boston, USA
BREAK
Critical windows of exposure: assessments and effects
Chair: Isabella Annesi-Maesano IDESP, INSERM & UM, Montpellier, France
Discussant: Paolo Vineis Imperial College, London, UK
Lecture 1: Martine Vrijheid ISGLOBAL, Barcelona, Spain
Lecture 2: Michael Jerret UCLA, Los Angeles, USA
Round Table: Exposome panorama in the world
Chair: Heimo Muller University of Graz, Austria
Discussant: Yuxia Cui NIEHS, Durham, NC, USA
Sophie Lanone Remedia
Gianluca Severi E3N and E4N
Gary Miller ERACLES
Martine Vrijhei HELIX and ATHLETE
Mircea Sofonea Expos’UM
Sylvain Sebert LONGITOOLS
Heikki Hyöty HEDIMED
Anjoeka Pronk and Eelco Juijpers EPHOR
Peter Hoet EXIMIOUS
Irene van Kamp EQUAL-LIFE
Jelle Vlaanderen and Roel Vermeulen EXPANSE
Zisis Kozlakidis HEAP
Isabella Annesi-Maesano and Denis Sarigiannis HEALS
Paolo Vineis EXPOSOMICS
BREAK
Causal estimates from high-dimensional heterogeneous data
Chair: Marc Chadeau Imperial College, London, UK
Discussant: David Causeur Agrocampus Ouest, Rennes, France
Lecture 1: Jelle Vlaanderen Utrecht University, Utrecht, The Netherlands
Lecture 2: Julie Josse IDESP, Montpellier, France
Lecture 3: Zeno Loi and Nicolas Molinari IDESP, Montpellier, France
The European Human Exposome Network
Chair: Yuxia Cui NIEHS,Durham, NC, USA
Introductory talk: Rita Araujo EC, Brussels, Belgium
Lecture 1: Data Harmonisation, FAIRificaton and Provenance Management (in Exposome Research)
Heimo Muller University of Graz, Austria
Lecture 2: HEAP data life-cycle: From data to knowledge discovery (for Exposome Research)
Roxana Martinez Karolinska Institute, Stockholm, Sweden
General discussion: All the Exposome projects
Lunch
Applying Exposomics to positively impact human health through recommendations and policy
Chair: Grégory Ninot IDESP, Montpellier, France
Discussant: Marco Martuzzi ISS, Rome, Italy
Lecture 1: Paolo Vineis Imperial College, London, UK
Lecture 2: The public health exposome: a population-based, exposure science approach to health disparities research,
Paul Juarez Research Center on Health Disparities, Equity, and the Exposome, Memphis, USA
Break
General discussion about unmet needs, projects and conclusion
Chair and discussant: Isabella Annesi-Maesano IDESP, INSERM et UM, Montpellier and Daniele di Pietro IMAG, CNRS, UM, Montpellier
Rémy Slama, ITMO SP, INSERM, Paris
Eric Delaporte INSERM, IRD, UM, Montpellier
Marc Chadeau Imperial College, London, UK
Robert Barouki INSERM, Paris, France
General discussion
Wrap-up
End of the symposium
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Avenue Gaston GIRAUD
34000 MONTPELLIER
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