Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to chronic diseases. The final aim is to help protect people at a societal level. However, the process of putting the emerging exposome approach to work in scientific research is hardly straightforward. There are many challenges to capturing the complexity of exposures in an individual across the lifetime and their potential health effects. The purpose of the forthcoming workshop is to collect scientists involved in building the exposome in the case of chronic diseases from fields ranging from clinical medicine, epidemiology, toxicology and omics to statistics, bioinformatics to review the state of the science in the emerging field of exposomics. The workshop will present the ongoing exposomics projects and initiative, including the GLOBAL EXPOSOME PLATEFORM.